Lipid peroxidation generates biologically active phospholipids including oxidatively N-modified phospholipids
نویسندگان
چکیده
منابع مشابه
Lipid peroxidation in cell membrane phospholipids
duced by reactive oxygen species and/or free radicals leads to alterations in the membrane structure and functions of cells, and has been proposed as a major mechanism for the onset of several pathological events in vivo, including postischemicreperfusion injury, cancer, senile dementia and aging. A number of studies have shown that peroxidation of membrane lipids in cells gives rise to highly ...
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Free radical–induced oxidation of membrane phospholipids generates complex mixtures of oxidized phospholipids (oxPLs). The combinatorial operation of a few dozen reaction types on a few dozen phospholipid structures results in the production of a dauntingly vast diversity of oxPL molecular species. Structural identification of the individual oxPL in these mixtures is a redoubtable challenge tha...
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The effect of dietary docosahexaenoic acid (DHA, C22:6n-3) with two lipid types on lipid peroxidation of the brain was investigated in streptozotocin (STZ)-induced diabetic mice. Each group of female Balb/c mice was fed a diet containing DHA-connecting phospholipids (DHA-PL) or DHA-connecting triacylglycerols (DHA-TG) for 5 wk. Safflower oil was fed as the control. The lipid peroxide level of t...
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Membranes of blood cells have an asymmetric bilayer distribution of phospholipid classes. In both erythrocytes and platelet plasma membranes the choline containing phospholipids (sphingomyelin and phosphatidylcholine) are preferentially located in the outer half of the membrane, whereas a large fraction of phosphatidylethanolamine and nearly all phosphatidylserine are confined to the cytoplasmi...
متن کاملNonheme iron in sickle erythrocyte membranes: association with phospholipids and potential role in lipid peroxidation.
Previous studies documented the abnormal association of heme and heme proteins with the sickle RBC membrane. We have now examined RBC ghosts and inside-out membranes (IOM) for the presence of nonheme iron as detected by its formation of a colored complex with ferrozine. Sickle ghosts have 33.8 +/- 18.2 nmol nonheme iron/mg membrane protein, and sickle IOM have 4.3 +/- 3.0 nmol/mg. In contrast, ...
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ژورنال
عنوان ژورنال: Chemistry and Physics of Lipids
سال: 2014
ISSN: 0009-3084
DOI: 10.1016/j.chemphyslip.2014.03.002